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Porovnávací studie bezobilných komplexních krmných směsí (KKS) pro morčata
POSTLOVÁ, Štěpánka
The purpose of this bachelor thesis was to compare commercially sold grain-free complex compound feeds (CCF) for guinea pigs. In particular, a comparison of the production technology, nutrient content and prices of the offered feeds. A total of 10 grain-free CFCs were compared and the results were discussed with literature. In particular, the production method of the feeds and the content of the main nutrients needed for the guinea pig were monitored. In addition, the feeds were compared based on their average price per kilogram. The ranking of the most suitable feeds was inducted from on the values, which were summarized in the cre-ated tables and graphs.
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Methods and consequences of some neurosurgical interventions in animal model and in human clinic. Pinealectomy and intracerebroventricular application.
Řezáčová, Lenka ; Tichý, Michal (advisor) ; Szárszoi, Ondrej (referee) ; Přibáň, Vladimír (referee)
Clinical surgical techniques of pinealectomy and intracerebroventricular (i.c.v) cannulation are still used in the clinic in indicated cases. In research, there is an effort to replace these classical surgical techniques by other means. However, these various new models often do not reflect the complexity of the functions taking place in the living organism as a whole. The thesis shows that these surgical techniques should be also a part of biomedical research in the future, as they still bring new important information. In the experiment, the pinealectomy can serve as a model of resection or depletion (removal of natural hormone secretion), while i.c.v. application of the active substance to the ventricles on the contrary as a model of addition or substitution. The practical part of the thesis is divided into 4 areas: A) pinealectomy - an animal models, B) pinealectomy - in the experiment, C) pinealectomy - in the clinical practice and D) intracerebroventricular application - in the experiment. The work describes in detail the surgical techniques and discuss possible consequences of pinealectomy in 6 animal species (and their comparison) and in humans. It also includes an experiment with pinealectomy in a rat and a clinical study in patients with pineal cyst and subsequent pinealectomy. The work...
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Sledování sociálního chování u morčat v modelové situaci
ELIÁŠ, Zdeněk
The aim of this work was to find out the social behaviour and interactions among the established group of guinea pigs (Cavia aperea var. porcellus) and the newly assembled groups, with each group being monitored three times, always for 24 hours. A total of 12 short-haired guinea pigs of smooth coat breed with balanced age distribution, divided into three groups, were monitored. The behaviour and activities of guinea pigs were recorded on a camcorder followed with subsequent evaluation of video recordings by means of ethograms and verbal description. Among monitored and evaluated activities were rest and sleep, feed and water intake, comfort behaviour, movement and conflict. In guinea pigs, there were proven differences in behaviour for all of the activities monitored. The individuality of individuals and their different behaviours manifested themselves, with each of them behaving a little bit differently from the others. By comparing the groups, significant differences in behaviour were found. Each individual behaved a little bit differently, but the same pattern of behaviour was not repeated among the groups. Also, it was found that the number of conflicts among guinea pigs decrease overtime for which the guinea pigs are together.
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Reproductive parameters of pet guinea pigs
KRHOUNOVÁ, Gabriela
The aim of this bachelor thesis was the observation and evaluation of female conception, as the main reproduction parameter, and the litter size in guinea-pig hobby breed. There were 50 litters evaluated in total and the results were compared with literature. In the experiment the date when the male was put in the group of females, the date of delivery and the size of the litter were recorded. The order of heat in which females got pregnant was calculated using these data. The results were visualized using tables and graphs. The results of female conceptions were considerably various, the majority of females, namely 28, became pregnant in the first heat, on the contrary, only one female became pregnant in their sixth heat. In the second, third and fourth heat total of 11, 4 and 6 respectively became pregnant. The exception was the fourth heat, while no female became pregnant. The litter sizes were also very different, females delivered from 1 to 6 pups. Four of the total 50 observed females delivered only one pup, 10 and 13 females had two and three pups respectively. The most common litter size was 4, delivered by 15 females; seven females had 5 pups and the largest size of six pups was in one case.
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Molecular typization of isolates from Arthroderma benhamiae complex, a zoonotic agent of epidemic dermatophytosis in Europe
Čmoková, Adéla ; Hubka, Vít (advisor) ; Hrabák, Jaroslav (referee)
Arthroderma benhamiae has been almost unknown among clinical mycologists but it is a cause of around 40 % of dermatophytic infections according to current studies in the Czech Republic. The species is primarily transmitted to humans from guinea pigs and other rodents. The epidemiological situation is similar in other countries in Central and Western Europe. The reason of significant increase in the incidence of infections has not been identified yet, and no sufficiently informative molecular markers have been developed for typification of the species that could help to resolve the cause of this problem. For the purposes of this study, isolates (n=268) from cases of human and animal dermatophytoses from the Czech Republic, Germany, Belgium, Switzerland, Italy, Japan and USA were selected. Ten variable microsatellite markers were developed and sequence analysis of two genetic loci (ITS rDNA and gpdh gene) were performed to reveal intraspecific variation. Phenotype was also studied at the level of micro- and macromorphology of the strains and growth parameters at several temperatures and on several cultivation media. Mating type idiomorph of each isolate was determined and mating experiments were performed by crossing pairs of genetically related as well as genetically distant strains. Sequence...
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Animal models of sporadic form of Alzheimer's disease
Popelíková, Anna ; Stuchlík, Aleš (advisor) ; Telenský, Petr (referee)
Alzheimer's disease is a severe illness affecting the elderly and its incidence increases markedly every year. To date, there is no effective treatment for this condition available, and the precise mechanism of the pathogenesis remains elusive (apart from the identification of certain genetic mutations as causes in a small percentage of cases). Also, no suitable animal model of this disease has been found so far. This paper provides a summary of non-transgenic models currently in use as well as newly introduced adepts, their characteristics and examples of their use in practice. It covers both rodent models mostly generated by external interventions to the brain tissue homeostasis of the experimental animals, and vertebrate species that have been reported to spontaneously develop Alzheimer's disease-like pathology: the so-called 'natural models'. Thus, this review might provide better orientation in the up-to-date progress of research of this disease.
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Popisné sledování sociálního chování skupin morčat
TŮMOVÁ, Tereza
The aim of the work was to find out and analyse social interactions and activities of the guinea pigs (Cavia aperea var. porcellus) during 24 hours. Five groups of short-haired guinea pigs were observed. The guinea pigs were filmed. Next, video records were analysed using ethograms and description of social behaviour between group members. Data record was written down to ethograms every 1 minute for a periof of 24 hours. Observed activities were food intake, resting (including sleep), movement and comfort beahaviour (grooming). Generally, eighteen guinea pigs (in five groups) were observed. Guinea pigs are friendly animals, they create stable and well-organised groups. None aggressive behaviour was observed between group members. Besides small conflicts because of age difference, food or interruption during sleep. The oldest sows were dominant and their place was close to food. It was found out that guinea pigs rested the most (726 minutes, half-day). Food intake made up 590 minutes (41 %) and movement 84 minutes (6 %). More active were younger guinea pigs and boar who was housed with two sows. Comfort behaviour took 41 minutes, guinea pigs also took cares of each other.
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The impact saturation feed ration of vitamine C on weight, health and reproduction on a selected brand of animals
TEJML, Petr
The aim of this study is to investigate the impact of vitamine C on weight, health and reproduction on a selected brand of rodents. The model animal was selected the guinea pig (Cavia aperea v. porcellus) whose sensitivity on the lack of vitamine C in food is well known. The guinea pig is not able to create vitamine C in its body like the man and its only possible posuply is in food. Vitamine C is characterised by a wide range of effect and its lack in the organism causes considerable ailments. The guinea pigs in the investigated breed were divided into several groups of similar constitution. Four groups were provided food containing added vitamin C, other four groups depended only on vitamin C present in food available in the season. The monitoring was carried out in 2005 and 2007. The weight of the guinea pigs was checked out every three days. The weigh, health and reproductive indexes were monitored during the whole experiment. According to the acquired results it is possible to affirm the importance of vitamin C in the life of guinea pigs. Guinea pigs that are not able to synthesise vitamine C by themselves are fully dependent on its supply in food. Consequently, in case of an insufficient amount of vitamine C in the food ration of a guinea pig is essential its subsequent addition. There are not many pieces of knowledge and written technical sources dealing with the breed of the guinea pig, therefore this study might represent an asset to the breeders and research.
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